Synthesis and Spectral Characterization of New Compounds Containing Benzotriazole Ring from 2 - chloro – N – (Substitutedphenyl) Acetamide

Authors

  • Ghazala Hashim Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, Al-Bayda, Libya.
  • Hanan Bashir Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, Al-Bayda, Libya.
  • Nsreen Abdalfarg Department of Chemistry, Faculty of Science, Omar Al-Mokhtar University, Al-Bayda, Libya.

DOI:

https://doi.org/10.37375/sjfssu.v3i1.837

Keywords:

o – phenylene diamine, 2 – chloro - N - (substituted phenyl) acetamide, 1H-benzo[d] 1,2,3-triazole, synthesis.

Abstract

A series of 2 – (1H – benzo[d] 1, 2, 3 – triazol -1 – yl) – N – (substituted phenyl) acetamide (3 -8) were synthesized by reacting 1H -benzo [d] 1, 2, 3 – triazole (2) and 2 - chloro – N – (substituted phenyl) acetamide (a1 - a6) in DMF in present K2CO3 was heated on the water bath.  1H – benzo [d] 1, 2, 3 – triazole (2) is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, showing a wide range of biological and pharmacological activities. Benzotriazole (2) can be synthesized by diazotization process using o -phenylene diamine with sodium nitrite and acetic acid. The synthesized compounds were isolated and purity was checked by the TLC method. The structures of all new benzotriazole derivatives were confirmed by melting point and spectroscopic methods (IR, 1HNMR, 13CNMR, Mass spectrometry, and elementary analysis). Furthermore, the purpose of this research is to synthesize some heterocyclic compounds that are of importance in the field of science and research. In addition, most of the studies based on benzotriazole derivatives possess a wide spectrum of biological activities including antibacterial, antifungal, antiviral, anti-inflammatory, antihypertensive, and analgesic properties.

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Published

2023-04-17

How to Cite

Ghazala, Bashir, H., & Abdalfarg, N. (2023). Synthesis and Spectral Characterization of New Compounds Containing Benzotriazole Ring from 2 - chloro – N – (Substitutedphenyl) Acetamide. Scientific Journal for Faculty of Science-Sirte University, 3(1), 54–60. https://doi.org/10.37375/sjfssu.v3i1.837