The cardiovascular function and growth of the developing embryo exposed to nicotine during the early stages of chicken embryo.
DOI:
https://doi.org/10.37375/sjfssu.v4i2.2877Keywords:
Nicotine, Developing embryo, Heart DisfunctionAbstract
Congenital malformations, present at birth, can be caused by genetic factors, environmental influences, or both. Nicotine exposure during pregnancy, whether due to passive smoke exposure or active smoking, is a significant environmental factor contributing to congenital malformations. Nicotine imitates acetylcholine, a natural chemical in the body, and its consumption by expectant mothers leads to growth delays, nervous system and cardiac abnormalities, and other abnormalities.
The aim of this study is to investigate the impact of nicotine on the early stages of embryonic development. The study focused on observing general morphological abnormalities in the development, and alterations in heart rate using domestic chick Galls galls embryos. Fertilized eggs were sterilized with 70% ethanol and then injected with three concentrations of nicotine solution (0.1, 0.3, and 0.5 mg/ml) on day zero before being placed in an incubator set at a temperature range of 37.5 - 38 Co. The current research indicated the effects of nicotine on the heart rate (HR) of chicken embryos treated at different stages, HH19 (Day 3), HH27 (Day 5), and HH36 (Day 10), with nicotine solutions in a decrease in HR. This suggests that nicotine has a notable effect on the heart rate of chicken embryos at various developmental stages.
References
Aoyagi, Y., N. Momoi, Y. Kanai, H. Go, Y. Abe, K. Miyazaki, Y. Tomita, M. Hayashi, K. Endo and M. Mitomo (2020). "Prenatal nicotine exposure affects cardiovascular function and growth of the developing fetus." Journal of Obstetrics and Gynaecology Research 46(7): 1044-1054.
Behnke, M., V. C. Smith, C. o. S. Abuse, C. o. Fetus, Newborn, M. Behnke, V. C. Smith, S. Levy, S. D. Ammerman, P. K. Gonzalez and S. A. Ryan (2013). "Prenatal substance abuse: short-and long-term effects on the exposed fetus." Pediatrics 131(3): e1009-e1024.
Chandrakar, M. R. and G. Pachlore (2023). "Effect of Cigarette Smoke on the Developing Embryo: Chick as an Animal Model." UTTAR PRADESH JOURNAL OF ZOOLOGY 44(3): 1-6.
Chou, H.-C. and C.-M. Chen (2014). "Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring." Reproductive Toxicology 50: 4-10.
Chuang, T.-D., A. Ansari, C. Yu, R. Sakurai, A. Harb, J. Liu, O. Khorram and V. K. Rehan (2020). "Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring." American Journal of Physiology-Heart and Circulatory Physiology 319(3): H651-H660.
Cruz, Y. P. (2012). Laboratory exercises in developmental biology, Academic Press.
Farsalinos, K. E., N. Yannovits, T. Sarri, V. Voudris and K. Poulas (2018). "Nicotine delivery to the aerosol of a heat-not-burn tobacco product: comparison with a tobacco cigarette and e-cigarettes." Nicotine and Tobacco Research 20(8): 1004-1009.
Feng, Y., M. Caiping, C. Li, R. Can, X. Feichao, Z. Li and X. Zhice (2010). "Fetal and offspring arrhythmia following exposure to nicotine during pregnancy." Journal of Applied Toxicology: An International Journal 30(1): 53-58.
Govind, A. P., P. Vezina and W. N. Green (2009). "Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction." Biochemical pharmacology 78(7): 756-765.
Greco, E. R., A. Engineer, T. Saiyin, X. Lu, M. Zhang, D. L. Jones and Q. Feng (2022). "Maternal nicotine exposure induces congenital heart defects in the offspring of mice." Journal of Cellular and Molecular Medicine 26(11): 3223-3234.
Honein, M. A., L. J. Paulozzi, T. Mathews, J. D. Erickson and L.-Y. C. Wong (2001). "Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects." Jama 285(23): 2981-2986.
JA, A. (2004). "The pathophysiology of cigarette smoking and cardiovascular disease." J Am Coll Cardiol 43: 1731-1737.
Karatza, A. A., I. Giannakopoulos, T. G. Dassios, G. Belavgenis, S. P. Mantagos and A. A. Varvarigou (2011). "Periconceptional tobacco smoking and Xisolated congenital heart defects in the neonatal period." International journal of cardiology 148(3): 295-299.
Ke, J., N. Dong, L. Wang, Y. Li, C. Dasgupta, L. Zhang and D. Xiao (2017). "Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring." Oncotarget 8(44): 76865.
Kim, B.-S., S.-J. Kim, H.-J. Kim, S.-J. Lee, Y.-J. Park, J. Lee and H.-K. You (2012). "Effects of nicotine on proliferation and osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells." Life sciences 90(3-4): 109-115.
Lambers, D. S. and K. E. Clark (1996). The maternal and fetal physiologic effects of nicotine. Seminars in perinatology, Elsevier.
Li, X., W. Li, G. Liu, X. Shen and Y. Tang (2015). "Association between cigarette smoking and Parkinson’s disease: a meta-analysis." Archives of gerontology and geriatrics 61(3): 510-516.
McGrath-Morrow, S. A., J. Gorzkowski, J. A. Groner, A. M. Rule, K. Wilson, S. E. Tanski, J. M. Collaco and J. D. Klein (2020). "The effects of nicotine on development." Pediatrics 145(3).
Melkonian, G., C. Le, W. Zheng, P. Talbot and M. Martins-Green (2000). "Normal patterns of angiogenesis and extracellular matrix deposition in chick chorioallantoic membranes are disrupted by mainstream and sidestream cigarette smoke." Toxicology and applied pharmacology 163(1): 26-37.
Mone, S. M., M. W. Gillman, T. L. Miller, E. H. Herman and S. E. Lipshultz (2004). "Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence." Pediatrics 113(Supplement_3): 1058-1069.
Parker, B. and V. P. Connaughton (2007). "Effects of nicotine on growth and development in larval zebrafish." Zebrafish 4(1): 59-68.
Perry, E. K. and R. H. Perry (2004). "Neurochemistry of consciousness: cholinergic pathologies in the human brain." Progress in Brain Research 145: 287-299.
Perry, M. F., H. Mulcahy and E. A. DeFranco (2019). "Influence of periconception smoking behavior on birth defect risk." American journal of obstetrics and gynecology 220(6): 588. e581-588. e587.
Piano, M. R., N. L. Benowitz, G. A. FitzGerald, S. Corbridge, J. Heath, E. Hahn, T. F. Pechacek, G. Howard and A. H. A. C. o. C. Nursing (2010). "Impact of smokeless tobacco products on cardiovascular disease: implications for policy, prevention, and treatment: a policy statement from the American Heart Association." Circulation 122(15): 1520-1544.
Rosenbruch, M., J. Kniepen and C. Weishaupt (1993). "The early chick embryo as a model to evaluate cardiovascular effects of adrenaline and nicotine." Toxicology in vitro 7(4): 541-545.
Saad, K. A. and R. A. Husayn (2024). "Nicotine exposure and its role in delaying the formation of long bones during embryonic development." African Journal of Advanced Pure and Applied Sciences (AJAPAS): 93-97.
Shan, M., K. Qamar and I. Iqbal (2015). "Role of nicotine and camellia sinensis on the developing femur of chick." J Pak Med Assoc 65(10): 1094-1096.
Shinawi, M., P. Liu, S.-H. L. Kang, J. Shen, J. W. Belmont, D. A. Scott, F. J. Probst, W. J. Craigen, B. H. Graham and A. Pursley (2010). "Recurrent reciprocal 16p11. 2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size." Journal of medical genetics 47(5): 332-341.
Silvey, M. and L. R. Brandão (2017). "Risk factors, prophylaxis, and treatment of venous thromboembolism in congenital heart disease patients." Frontiers in pediatrics 5: 146.
Slotkin, T. A. and J. Bartolome (1986). "Role of ornithine decarboxylase and the polyamines in nervous system development: a review." Brain research bulletin 17(3): 307-320.
Smith, A. M., L. P. Dwoskin and J. R. Pauly (2010). "Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences." Journal of pediatric biochemistry 1(02): 125-141.
Somm, E., V. M. Schwitzgebel, D. M. Vauthay, M. L. Aubert and P. S. Hüppi (2009). "Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders." Molecular and cellular endocrinology 304(1-2): 69-77.
Vaupel, D. B., S. R. Tella, D. L. Huso, V. O. Wagner, A. G. Mukhin, S. I. Chefer, A. G. Horti, E. D. London, A. O. Koren and A. S. Kimes (2004). "Pharmacological and toxicological evaluation of 2-FA-85380, a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography." Journal of Pharmacology and Experimental Therapeutics.
Yuan, M., S. J. Cross, S. E. Loughlin and F. M. Leslie (2015). "Nicotine and the adolescent brain." The Journal of physiology 593(16): 3397-3412.
Zhang, D., H. Cui, L. Zhang, Y. Huang, J. Zhu and X. Li (2017). "Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies." The Journal of Maternal-Fetal & Neonatal Medicine 30(6): 645-657.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Scientific Journal for Faculty of Science-Sirte University
This work is licensed under a Creative Commons Attribution 4.0 International License.
