Comparative Study of Hematological and Biochemical Parameters in Patients with Renal Failure Depending on Gender


  • Fawziya B. Marie Department of Zoology, Faculty of Science, University of Sirte, Libya
  • Fathia A. Mosa Department of Chemistry, Faculty of Science, University of Sirte, Libya
  • Mabrouka B. Abdullah Department of Zoology, Faculty of Science, University of Sirte, Libya
  • Samah A. Abdul Department of Zoology, Faculty of Science, University of Sirte, Libya
  • Sondos S. Naji Department of Zoology, Faculty of Science, University of Sirte, Libya



Renal failure, urea, creatinine, haemoglobin, haematological parameters, CBC.


The research aimed to evaluate the hematological and biochemical parameters in patients with kidney failure who are being treated at the nephrology department. This study was performed on 100 samples (50 males and 50 females) of patients who attended the nephrology department at Ibn Sina University Hospital. The survey of these samples was carried out among patients attending from January to May 2023. This study depended on the analysis of individual samples obtained from patient records, expressed as complete blood count (CBC) as well as biochemical changes in kidney function. It was found that most patients suffered from a decrease in hemoglobin, WBCs, and RBC levels. According to the obtained results in this study, we found a significant decrease in the concentrations of hemoglobin, platelets, and leukocytes in both genders, while we found a significant increase in the concentrations of urea and creatinine. The results revealed no decline in potassium ions in patients, but sodium ions slightly decreased somewhat in males alone and not in females.


Akkari, K. (2022). Projecting requirements for end stage renal disease services in Libya 2014-2024. Ibnosina Journal of Medicine and Biomedical Sciences, 5(06), 354-362.

Al-Abachi, S. Z., Mustafa, L. A., Hassan, D. S. K., & Al-Hadidi, A. A. (2012). Study of some biochemical changes in serum of patients with chronic renal failure. Iraqi National Journal of Chemistry, 12(46), 270-280.

Begum, S., & Latunde-Dada, G. O. (2019). Anemia of Inflammation with An Emphasis on Chronic Kidney Disease. Nutrients, 11(10), 2424.

Benzing, T., & Schumacher, B. (2023). Chronic kidney disease promotes ageing in a multiorgan disease network. Nature Reviews Nephrology, 19(9), 542–543.

Besarab, A., Amin, N., Ahsan, M., Vogel, S.E., Zazuwa, G., Frinak, S., Zazra, J.J., Anandan, J.V. & Gupta, A. (2000). Optimization of epoetin therapy with intravenous iron therapy in hemodialysis patients. Journal of the American Society of Nephrology, 11(3), 530-538.

Billett, H. H. (1990). Hemoglobin and hematocrit. Clinical Methods - NCBI Bookshelf.

Bolignano, D., Lennartz, S., Leonardis, D., D'arrigo, G., Tripepi, R., Emrich, I.E., Mallamaci, F., Fliser, D., Heine, G. & Zoccali, C. (2015). High estimated pulmonary artery systolic pressure predicts adverse cardiovascular outcomes in stage 2–4 chronic kidney disease. Kidney international, 88(1), 130-136.

Brunelli, S. M., & Berns, J. S. (2009). Anemia in chronic kidney disease and end-stage renal disease. Nephrology Rounds, 7(8), 1-6.

Chadban, S. J., Briganti, E. M., Kerr, P. G., Dunstan, D. W., Welborn, T. A., Zimmet, P. Z., & Atkins, R. C. (2003). Prevalence of kidney damage in Australian adults: The AusDiab kidney study. Journal of the American Society of Nephrology, 14(suppl_2), S131-S138.

Chhetri, P. K., Manandhar, D. N., Bhattarai, S. P., Pahari, L. R., & Shrestha, R. (2008). Chronic kidney disease 5 on hemodialysis in Nepal medical college teaching hospital. Nepal Med Coll J, 10(1), 8-10.

Costa, E., Rocha, C., Rocha-Pereira, P., Castro, E., Miranda, V., Faria, M. D. S., Quntannilha, A.; Belo, L. & Santos-Silva, A. (2008). Band 3 profile as a marker of erythrocyte changes in chronic kidney disease patients. The Open Clinical Chemistry Journal, 1(1): 57-63.

Erslev, A. J., & Besarab, A. (1997). Erythropoietin in the pathogenesis and treatment of the anemia of chronic renal failure. Kidney International, 51(3), 622-630.

Genovese, G., Friedman, D.J., Ross, M.D., Lecordier, L., Uzureau, P., Freedman, B.I., Bowden, D.W., Langefeld, C.D., Oleksyk, T.K., Uscinski Knob, A.L. and Bernhardy, A.J. (2010). Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science, 329(5993), 841-845.

Goleg, F. A., Kong, N. C. T., & Sahathevan, R. (2014). Dialysis-treated end-stage kidney disease in Libya: Epidemiology and risk factors. International urology and nephrology, 46, 1581-1587.

Hsu, C. Y., Bates, D. W., Kuperman, G. J., & Curhan, G. C. (2001). Relationship between hematocrit and renal function in men and women. Kidney international, 59(2), 725-731.

John, R., Webb, M., Young, A., & Stevens, P. E. (2004). Unreferred chronic kidney disease: a longitudinal study. American Journal of Kidney Diseases, 43(5), 825-835.

Kaka, N., Sethi, Y., Patel, N., Kaiwan, O., Al-Inaya, Y., Manchanda, K., & Uniyal, N. (2022). Endocrine manifestations of chronic kidney disease and their evolving management: A systematic review. Disease-A-Month, 68(12), 101466.

Kausz, A. T., Obrador, G. T., & Pereira, B. J. (2000). Anemia management in patients with chronic renal insufficiency. American journal of kidney diseases, 36(6), S39-S51.

Kellum, J. A., Romagnani, P., Ashuntantang, G., Ronco, C., Zarbock, A., & Anders, H. (2021). Acute kidney injury. Nature Reviews Disease Primers, 7(1).

Kelly, F.J., Anderson, S., Thompson, M.M., Oyama, T.T., Kennefick, T.M., Corless, C.L., Roman, R.J., Kurtzberg, L., Pratt, B.M. & Ledbetter, S. R. (1999). Acute and chronic renal effects of recombinant human TGF-β2 in the rat. Journal of the American Society of Nephrology, 10(6), 1264-1273.

Khan, R. N., Vohra, E. A., & Suleman, W. (2005). Factors determining outcome of acute renal failure patients. Journal-Pakistan Medical Association, 55(12), 526.

Kopple, J. D., Kalantar-Zadeh, K., & Mehrotra, R. (2005). Risks of chronic metabolic acidosis in patients with chronic kidney disease. Kidney International, 67(95), S21-S27.

Kralova, S., Leva, L., & Toman, M. (2009). Polymorphonuclear function in naturally occurring renal failure in dogs. Veterinární medicína, 54(5), 236-243.

Kumar, A. (2003). Animal physiology. Discovery Publishing House.

Lafrance, J. P., & Miller, D. R. (2010). Acute kidney injury associates with increased long-term mortality. Journal of the American Society of Nephrology: JASN, 21(2), 345.

Lee, M. (Ed.). (2009). Basic skills in interpreting laboratory data. ASHP.

Macdougall, I., Bock, A. H., Carrera, F., Eckardt, K. U., Gaillard, C. A., Van Wyck, D. B., ... & Roger, S. D. (2016). CHRONIC KIDNEY DISEASE ANAEMIA. Nephrology Dialysis Transplantation, 31(1), i193-i199.

Marshall, A. L. (2022). Williams Manual of Hematology. Mcgraw-Hill Education.

McClellan, W. M., & Powe, N. R. (2009). Introduction to the Proceedings of a Centers for Disease Control and Prevention Expert Panel Workshop: Developing a comprehensive public health strategy for preventing the development, progression, and complications of CKD. American Journal of Kidney Diseases, 53(3), S1-S3.

Meri, M. A., Al-Hakeem, A. H., Al-Abeadi, R. S., & Mahdi, D. M. (2022). Study of the changes of some biochemical parameters of patients with renal failure. Bulletin of National Institute of Health Sciences, 140(3), 2925-2933.

Nairz, M., Theurl, I., Wolf, D., & Weiss, G. (2016). Iron deficiency or anemia of inflammation? Differential diagnosis and mechanisms of anemia of inflammation. Wiener Medizinische Wochenschrift, 166(13-14), 411-423.

Perco, P., Pleban, C., Kainz, A., Lukas, A., Mayer, G., Mayer, B., & Oberbauer, R. (2006). Protein biomarkers associated with acute renal failure and chronic kidney disease. European journal of clinical investigation, 36(11), 753-763.

Prasad, G. R. (2014). Metabolic syndrome and chronic kidney disease: Current status and future directions. World journal of nephrology, 3(4), 210.

Priyadarshani, W. V. D., de Namor, A. F. D., & Silva, S. R. P. (2023). Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps. Environmental geochemistry and health, 45(6), 2647-2662.

Remuzzi, G. (1989). Bleeding disorders in uremia: pathophysiology and treatment. Advances in nephrology from the Necker Hospital, 18, 171-186.

Saxena, R., Sharma, G., & Gulati, N. (2018). Iron-deficiency Anemia and Chronic Kidney Disease: An Overview. World Journal of Anemia, 2(3and4), 85–89.

Shastry, I., & Belurkar, S. (2019). The spectrum of red blood cell parameters in chronic kidney disease: A study of 300 cases. Journal of Applied Hematology, 10(2), 61-66.

Somvanshi, S., Khan, N. Z., & Ahmad, M. (2012). Anemia in chronic kidney disease patients. Clinical Queries: Nephrology, 1(3), 198-204.

Srinivasan, R., Fredy, I. C., Chandrashekar, S., Saravanan, J., Mohanta, G. P., & Manna, P. K. (2016). Assessment of erythropoietin for treatment of anemia in chronic kidney failure-ESRD patients. Biomedicine & Pharmacotherapy, 82, 44-48.

Tyagi, N. (2023) Serum Creatinine Test: Means, Normal Range, Price, Procedure, retrieved from:

Vaidya, S. R., & Aeddula, N. R. (2022, October 24). Chronic kidney disease. StatPearls - NCBI Bookshelf.

Zilva, J. F., & Pannall, P. R. (1988). Clinical chemistry in diagnosis and treatment. 5th ed., Edward Arnold, London, UK.




How to Cite

Marie, F. B., Mosa, F. A., Abdullah, M. B., Abdul, S. A., & Naji, S. S. (2024). Comparative Study of Hematological and Biochemical Parameters in Patients with Renal Failure Depending on Gender. Scientific Journal for Faculty of Science-Sirte University, 4(1), 117–123.