Morphological Study of the Effects of Caffeine Beverages Can Cause Birth Defects on Swiss White Mice Embryos
DOI:
https://doi.org/10.37375/sjfssu.v1i1.65Keywords:
Embryos, Malformations, Caffeine beverages, Mice embryos.Abstract
The current study was conducted to identify the effects of different doses of Arabic coffee, black tea and Coca-Cola syrup on the possibility of birth defects in Swiss white mice embryos. (25) pregnant female mice were used in the study, divided into five experimental groups, including the control group dosed with distilled water, and four experimental groups were dosed with concentrations (4000-2500-2000-1000) mg/kg body weight for Arabic coffee and black tea and (2,3,4,6 ml/kg) for Coca-Cola syrup; once a day, from the seventh day until the eighteenth day of pregnancy.
The results of the current study showed cases of abortion and fetal death at varying degrees and many abnormalities in white mouse embryos due to the different concentrations of the beverages used were characterized by the appearance of elongated and enlarged embryos. The elongation and deformation of the fetus, And the embryos mutated. Small embryos folded like a ball and curved in the shape of letter C, and the severity of the deformities increased by the appearance of mutated embryos resembling the body of a fish and deformed embryos similar to a water mermaid and not fully developed and the appearance of the head in the shape of a blurred triangle, as well as forward with a pointed end resembling a bird's beak, and brain deformation through depression in the posterior cranial region of the skull, and for the first time a new deformation is a cerebral Meningomyelocele in the form of a cystic tumor in the posterior brain region.
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