Knowledge, Diagnostic Approaches, and Management Patterns of Laryngopharyngeal Reflux among Primary Care Physicians and Otolaryngologists: A Cross-Sectional Study”

Authors

  • Hawa Mohamed Saad Department of Otorhinolaryngology, Faculty of Medicine, Sirt University, Sirte, Libya
  • Eman Hassan aboshawesha Department of Otorhinolaryngology, Faculty of Medicine, Elmarje university, Benghazi, Libya
  • Naima Alsanousi Department of Otorhinolaryngology, Faculty of Medicine, Benghazi university, Benghazi, Libya

DOI:

https://doi.org/10.37375/susj.v16i1.4101

Keywords:

Laryngopharyngeal reflux, physician knowledge, diagnosis, management, primary care, otolaryngology

Abstract

Background: Laryngopharyngeal reflux (LPR) is an extraesophageal manifestation of gastroesophageal reflux disease (GERD) that often presents with nonspecific symptoms, posing challenges in diagnosis and management. Variability in physician knowledge, diagnostic approaches, and treatment strategies may adversely affect patient outcomes. This study aimed to assess and compare the knowledge, diagnostic practices, and management patterns of LPR among primary care physicians and otolaryngologists.

Methods: A cross-sectional survey was conducted among 197 physicians, including primary care physicians and otolaryngologists. A structured questionnaire was used to evaluate knowledge of LPR pathophysiology, symptom recognition, differentiation from GERD, diagnostic approaches, and management strategies, including pharmacologic treatment, lifestyle modification, dietary counseling, and referral practices. Data were analyzed using descriptive statistics and presented as frequencies and percentages, stratified by specialty.

Results: Overall, 58% of participants demonstrated adequate knowledge of LPR, with significantly higher levels among otolaryngologists compared to primary care physicians (72% vs. 44%). Recognition of LPR as an extraesophageal condition was reported by 72% of respondents (90% vs. 54%), awareness of “silent reflux” by 65% (80% vs. 50%), and correct differentiation from GERD by 60% (76% vs. 44%).

Diagnostic approaches differed substantially between groups. Primary care physicians predominantly relied on symptom-based assessment (80%) and empirical proton pump inhibitor (PPI) trials (76%), whereas otolaryngologists more frequently utilized laryngoscopy (80%) and standardized diagnostic tools (36%). Referral rates were also higher among otolaryngologists (50% vs. 24%).

In terms of management, PPIs were the most commonly prescribed therapy (84% among primary care physicians vs. 90% among otolaryngologists). However, otolaryngologists were more likely to recommend lifestyle modifications (64% vs. 36%), dietary counseling (56% vs. 30%), combination therapy (50% vs. 20%), and referral for further evaluation (40% vs. 16%).

Conclusion: Significant variability exists in physicians’ knowledge, diagnostic approaches, and management of LPR. Otolaryngologists demonstrate more comprehensive and guideline-oriented practices, whereas primary care physicians rely more heavily on empirical pharmacologic therapy. Targeted educational interventions, implementation of standardized diagnostic tools, and greater emphasis on lifestyle and dietary modifications are recommended to improve early diagnosis and optimize patient outcomes.

References

Kim, G.H. and Fass, R., 2025. Potassium-competitive acid blockers for treatment of extraesophageal symptoms and signs. Journal of Neurogastroenterology and Motility, 31(2), p.170.

Yadlapati, R., Weissbrod, P., Walsh, E., Carroll, T.L., Chan, W.W., Gartner-Schmidt, J., Guadagnoli, L., Jette, M., Myers, J.C., O'rourke, A. and Sweis, R., 2026. The San Diego Consensus for laryngopharyngeal symptoms and laryngopharyngeal reflux disease. Official journal of the American College of Gastroenterology| ACG, 121(2), pp.322-336.

Savarino, E.V., Lechien, J.R. and Bertin, L., 2025. Pathophysiology of laryngopharyngeal reflux disease: the reflux vs reflex theory. Otolaryngologic Clinics of North America, 58(3), pp.403-413.

Chen, G. and Lechien, J.R., 2025. Human vocal fold tissue modifications related to laryngopharyngeal reflux disease: a systematic review. Journal of Voice.

Wang, J., Zhou, Y. and Lei, D., 2025. Relationship between laryngopharyngeal reflux, gastroesophageal reflux disease, and dental erosion in adult populations: a systematic review. Digestive Diseases and Sciences, 70(3), pp.1078-1090.

Wang, Y., Liang, Q., Luo, J., Miao, H., Qin, G. and Bao, Y., 2025. Laryngopharyngeal reflux in otolaryngology-head and neck surgery clinic: an epidemiological survey. Ear, Nose & Throat Journal, 104(8), pp.NP510-NP517.

Chen, C.C., Chou, C.K., Yuan, M.C., Tsai, K.F., Wu, J.F., Liao, W.C., Chiu, H.M., Wang, H.P., Wu, M.S. and Tseng, P.H., 2025. Effect of anti-reflux mucosal ablation on esophageal motility in patients with gastroesophageal reflux disease: a study based on high-resolution impedance manometry. Journal of Neurogastroenterology and Motility, 31(1), p.75.

Komolafe, K., Komolafe, T.R., Crown, O.O., Ajiboye, B., Noubissi, F., Ogungbe, I.V. and Graham, B., 2025. Natural products in the management of gastroesophageal reflux disease: mechanisms, efficacy, and future directions. Nutrients, 17(6), p.1069

Gelardi, M., Giancaspro, R., Fiorentino, C., Patruno, S., Marroni, J., D’Avino, A., Neri, L., Cassano, M. and Neri, G., 2025. Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study. Frontiers in medicine, 12, p.1488323.

Eiamkulbutr, S., Dumrisilp, T., Sanpavat, A. and Sintusek, P., 2023. Prevalence of gastroesophageal reflux disease in children with extraesophageal manifestations using combined-video, multichannel intraluminal impedance-pH study. World Journal of Clinical Pediatrics, 12(3), p.151.

Abraham, Z.S. and Kahinga, A.A., 2022. Utility of reflux finding score and reflux symptom index in diagnosis of laryngopharyngeal reflux disease. Laryngoscope Investigative Otolaryngology, 7(3), pp.785-789.

Visaggi, P., Mariani, L., Svizzero, F.B., Tarducci, L., Sostilio, A., Frazzoni, M., Tolone, S., Penagini, R., Frazzoni, L., Ceccarelli, L. and Savarino, V., 2022. Clinical use of mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index for the diagnosis of gastro-esophageal reflux disease. Esophagus, 19(4), pp.525-534.

Florou, V., D KARKOS, P., Marini, K., Lechien, J.R., Paikos, D., Skoulakis, C. and Hajiioannou, J., 2022. Laryngopharyngeal Reflux and Olfaction Disorders. Is There Any Connection? A Scoping Review. Maedica, 17(2), p.471.

Syropoulos, S., Moutzouri, M., Grammatopoulou, E. and Patsaki, I., 2026. Impact of Inspiratory Muscle Training in Individuals with Gastroesophageal Reflux Disease: A Randomized Controlled Trial Protocol. Methods and Protocols, 9(2), p.32.

Getsuwan, S., Tanpowpong, P., Butsriphum, N., Lertudomphonwanit, C., Thirapattaraphan, C., Thanachatchairattana, P. and Treepongkaruna, S., 2023. Prediction of refractory gastroesophageal reflux disease in young children. Pediatrics International, 65(1), p.e15645.

Ayazi, S. and Jobe, B., 2023. Laryngopharyngeal Reflux and Pulmonary Manifestations. In The AFS Textbook of Foregut Disease (pp. 49-55). Cham: Springer International Publishing.

Ragaee, M.A., Sedik, S.S., Ahmed, H.A.E.R.M., Mahran, E.E.M.O. and Roushdy, M.M., 2023. Proton pump inhibitors as treatment of laryngeal disorders among patients with gastroesophageal reflux disease: A single-arm (pre and post) quasi-experimental study. The Egyptian Journal of Otolaryngology, 39(1), p.10.

Zdrhova, L., Bitnar, P., Friedl, L., Mares, J., Madle, K., Balihar, K., Kolar, P., Kozeluhova, J., Fox, M. and Martinek, J., 2025. Effect of Diaphragmatic Breathing Training on the Esophagogastric Junction and Esophageal Motility in Patients With Reflux Symptoms. Neurogastroenterology & Motility, 37(12), p.e70172.

Lechien, J.R., 2023. Sensitivity, specificity, and predictive values of laryngopharyngeal reflux symptoms and signs in clinical practice. Otolaryngology–Head and Neck Surgery, 169(1), pp.97-104.

Lien, H.C., Lee, P.H. and Wang, C.C., 2023. Diagnosis of laryngopharyngeal reflux: past, present, and future—a mini-review. Diagnostics, 13(9), p.1643.

Guo, W., Zhang, J., Yue, H., Lyu, K., Chen, S., Huang, B., Wang, Y. and Lei, W., 2024. The reflux symptom score has good screening value for laryngopharyngeal reflux. BMC gastroenterology, 24(1), p.346.

Sagandykova, K., Papulova, N., Muhamadieva, G.M., Azhenov, T. and Lechien, J.R., 2025. The diagnostic accuracy of the nasopharyngeal reflux endoscopic score (NRES) for identifying laryngopharyngeal reflux disease in chronic rhinosinusitis. Journal of Clinical Medicine, 14(12), p.4293.

Hounki, A.M., Hassan, A.I., Alshetwy, N.A. and Ahmed, K.A., 2025. Disposable Retrieval Bag Significantly Reduces Surgical Site Infections After Laparoscopic Appendectomy: A Retrospective Analysis. African Journal of Advanced Pure and Applied Sciences, pp.569-574.

Ahmed, K.A. and Alhendwi, N.Y., 2025. Diagnostic challenges in dental pathology: Case-based insights for practitioners (case study review). Scholastic Dental Sciences, 1(2), pp.01–03.

Hounki, A., Youns, E. and Glia, A., 2025. Laparoscopic Repair of a Giant Hiatal Hernia with Nissen Fundoplication in a Patient with Dyspnea and Severe GERD: A Case Report. Libyan Medical Journal, pp.468-472.

Published

2026-06-24