The Efficacy of Adding Midazolam As An Adjuvant To Lidocaine Bupivacaine Mixture In Ultrasound Guided Supraclavicular Block

Authors

  • Jomaa faraj abdallah alrjael Department of anesthesia and ICU faculty of medicine, Sirte University, sirte, Libya

DOI:

https://doi.org/10.37375/susj.v15i2.3732

Keywords:

Midazolam, Bupivacaine, Supraclavicular Block, Ultrasound

Abstract

Background: Brachial plexus block is useful technique that serves as a valuable alternative to general anesthesia for procedures involving the upper limbs. It provides optimal muscle relaxation, stable intra-operative hemodynamics and effective post-operative pain control.

The purpose of this work was to assess the effectiveness of adding midazolam to local anesthetic mixture (lidocaine /bupivacaine) for analgesia and anesthesia in supraclavicular block with ultrasound-guidance during upper limb surgeries.

 Patients and methods: 40 patients from those scheduled to unilateral upper limb surgery below the level of midarm.at our hospital. The patients were allocated into two equal groups. Group ''M'' (lidocaine bupivacaine) mixture + Midazolam, and group ''C'' (lidocaine bupivacaine). Results Our results showed that there was no difference between the two groups regarding sensory onset. In contrast, patients in group M showed an earlier onset of motor block. Furthermore, both sensory and motor block durations were longer in Midazolam than control group. There was no difference between the 2 groups regarding respiratory rate, ECG, blood pressure, pulse rate and oxygen saturation.

Conclusion: From of the findings of this study, we conclude that adding midazolam to mixture of bupivacaine 0.25 % and Lidocaine 1 % for supraclavicular brachial plexus block results in rapid onset of sensory block and prolongs both sensory and motor block duration.

References

Akkenapalli A K , Sasidhar G V (2016) A comparative study of brachial plexus block using bupivacaine with midazolam and bupivacaine alone in upper limb surgeries. IAIM. 3(11): 69-77.

Bazin J E , Massoni C and Bruelle P, et al (1997) The addition of opioids to LA in brachial plexus block the comparative study of effects of morphine, buprenorphine and sufentanyl.Anaesthesia.52(9):858-62.

El-Baradey G F and Elshmaa N S (2014) The efficacy of adding dexamethasone, midazolam, or epinephrine to 0.5% bupivacaine in supraclavicular brachial plexus block. Saudi J Anaesth. (1):78-83.

Gautam S N, Bhatta S K and Sharma N R (2013) A comparison on brachial plexus block using local anesthetic agents with and without midazolam. J Chitwan Med Coll. 3(1): 11-13.

Jarbo K , Batra Y K , Panda N B (2005) Brachial plexus block with midazolam and bupivacaine improves analgesia.CanJAnesth.52(8):822-6.

Jagadish C M and Pradip K M ( 2017 ) A clinical comparison between bupivacaine midazolam combination and bupivacaine plain in brachial plexus block by supraclavicular approach. IAIM, 4(11):106-14.

Keeler J F, Simpson K H , Ellis F R , et al (1992) Effect of addition of hyaluronidase to bupivacaine during axillary brachial plexus block. Br J Anaesth.68(1):68-71.

Kopp S L, Wedel DJ and Rowlingson JC ,et al (2010) Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition) Regional Anesthesia and Pain Medicine. 35(1):64-101

Kumari I , Gehlot R K and Verma R , et al (2017) Comparison of two different doses of dexmedetomidine added to ropivacaine in patients posted for upper limb surgery under supraclavicular brachial plexus block , anaesthesia, pain & intensive care.21(2):141.

Moharam S A , Basuoni A S and Abd-elhafez A A , et al (2017 ) Evaluation of midazolam as an adjuvant to bupivacaine in supraclavicular brachial plexus block. Tanta Med J.45(2):99-103

Nazir N and Jain S (2017) Randomized Controlled Trial for Evaluating the Analgesic Effect of Nalbuphine as an Adjuvant to Bupivacaine in Supraclavicular Block under Ultrasound Guidance Anesth Essays Res. 11(2): 326–9.

Nishiyama T , Matsukawa T and Hanoaka K (2002) Effects of adding midazolam on postop analgesia with two different doses of bupivacaine. J Clin Anesth.14(2):92-7.74.

Raghu R , Indira P and Kiran M , et al (2015) A comparative study of 0.375% bupivacaine with midazolam and 0.375% bupivacaine for brachial plexus block in upper limb surgeries. Asian Pac. J. Health Sci. 2(4):29-135.

Shaikh S I , and Veena K , (2012) Midazolam as an adjuvant in supraclavicular brachial plexus block . Anaesth Pain & Intensive Care.16(1):7-11.

Singh J, Verma V and Sood P, et al (2016) . Midazolam as an adjunct to lignocaine at two different doses in ultrasound-guided supraclavicular brachial plexus block: a randomized controlled trial. Ain-Shams J Anaesthesiol.9(4):549-57.

Winnie A P, Tay C H and Patel K P (1977)Pharmacokinetics of local anaesthetics during plexus blocks. Anesth Analg.56(6): 852-61.

Yadav RK, Sah BP and Kumar P, et al (2008) Effectiveness of addition of neostigmine or dexamethasone to local anaesthetic in providing perioperative analgesia for brachial plexus block: A prospective, randomized, double blinded, controlled study. Kathmandu Univ Med J (KUMJ).6(23):302-9.

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Published

2025-12-24