Study of Reactions of 2,2-Dichloro-N-(Substituted Phenyl) Acetamide With 1H-Benzo[d]1,2,3-Triazole


  • Ghazala Hashim Department of Chemistry, Faculty of Science, Omer Al-Mukhtar University, El-Beida- Libya,
  • Hanan Bashir Department of Chemistry, Faculty of Science, Omer Al-Mukhtar University, El-Beida- Libya.
  • Nsreen A. Abdalfarg Department of Chemistry, Faculty of Science, Derna University, Libya


Substituted aniline, Dichloroacetyl chloride, 1H – benzo [d] 1,2,3 - triazole, Synthesis


Synthesis of 2,2-dichloro-N-(substituted phenyl) acetamid (a1-4) via treated substituted aniline with dichloroacetyl chloride in the present of anhydrous K2CO3 in CH2Cl2. The later 1H-benzo[d]1,2,3-triazole (2) were reacted with 2,2-dichloro-N-(4-chloro phenyl) acetamid (a1), 2,2-dichloro-N-(3-nitro phenyl) acetamid (a2), 2,2-dichloro-N-(4-methoxy-3-nitrophenyl) acetamid (a3), 2,2-dichloro-N-(p-tolyl) acetamid (a4) in the present of  anhydrous K2CO3 in acetone under reflux to give 2-(1H-benzo[d]1,2,3-triazol-1-yl)-2-chloro-N-(4-chloro phenyl) acetamide (3), 2-(1H-benzo[d]1,2,3-triazol-1-yl)-2-chloro-N-(3-nitro phenyl) acetamide (4), 2-(1H-benzo[d]1,2,3-triazol-1-yl)-2-chloro-N-(4-methoxy-3-nitro phenyl) acetamide (5) and 2-(1H-benzo[d]1,2,3-triazol-1-yl)-2-chloro-N-(p-tolyl) acetamide (6) respectively.

All the synthesized compounds were characterized on the basis of melting point, TLC, IR, 1HNMR, 13CNMR and mass spectrometry.


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