Concentration of Lead, Cadmium, Zinc and Iron in maternal blood and umbilical cord in Zeliten city, Libya
الكلمات المفتاحية:
heavy metals، maternal blood، umbilical cordالملخص
The present study was carried out to determine the lead, cadmium, zinc and iron concentration in maternal and umbilical cord blood. Samples were collected from Zeliten delivery hospital in the period from February to April 2018. A total of 70 pregnant women participated in this study, We compared the concentration of Lead, Cadmium, Zinc and Iron in maternal blood and umbilical cord. There is significant difference in maternal blood concentration of iron compared with umbilical cord blood iron concentration (P value 0.047), while there is no significant difference found in concentration of other studied metals (Zn, Fe, Cd).
المراجع
- Gascon M, Morales E, Sunyer J, Vrijheid M. Effectsof persistent organic pollutants on the developingrespiratory and immune systems: a systematic review.Environ Int (2013); 52: 51-65.
- Scheen AJ, Giet D. Role of environment in complexdiseases: air pollution and food contaminants.Rev Med Liege (2012); 67: 226-233.
- Prüss-Ustün A, Vickers C, Haefliger P, Bertollini R.Knowns and unknowns on burden of disease dueto chemicals: a systematic review. Environ Health(2011); 10: 9
- Prasher D. Heavy metals and noise exposure: health effects. Noise Health (2009); 11: 141-144.
- Järup L. Hazards of heavy metal contamination. Br Med Bull (2003); 68: 167-182
- Man M, Naidu R, Wong MH. Persistent toxic substances released from uncontrolled e-waste recycling and actions for the future. Sci Total Environ (2012) Jul 26. Hj
- Caserta D, Mantovani A, Ciardo F, Fazi A, Baldi M, Sessa MT, La rocca C, Ronchi A, Moscarini M, Mi Noia C. Heavy metals in human amniotic fluid: a pilot study. Prenat Diagn (2011); 31: 792-796.
- Lozano J, García-Algar O, Vall O, Delatorre R, Scaravelli G, Pichini S. Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit (2007); 29: 711-734.
- Lewicka I, Kocyłowski R, Grzesiak M, Gaj Z, Oszukowski P, and Suliburska J. Selected trace elements concentrations in pregnancy and their possible role - literature review.Ginekologia Polska(2017); 88 (9): 509–514.
- Reyes JL, Molina-Jijón E, Rodríguez-muñoz R, Bautista-García P, Debray-García Y, Namorado Mdelc. Tight junction proteins and oxidative stress in heavy metals-induced nephrotoxicity. Biomed Res Int (2013); 2013: 730-789.
- Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M. Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol (2011); 3195-107.
- Farina M, Rocha JB, Aschner M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci (2011); 89: 555- 563.
- Baranowska-Bosiacka I, Gutowska I, Rybicka M, Nowacki P, Chlubek D. Neurotoxicity of lead. Hypotheticalmolecular mechanisms of synaptic functiondisorders. Neurol Neurochir Pol (2012); 46:569-578.
- Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology (2011); 283: 65-87.
- Simonsen LO, Harbak H, Bennekou P. Cobalt metabolism and toxicology--a brief update. Sci Total Environ (2012) ; 432: 210-215.
- Tseng CH. The potential biological mechanisms of arsenic-induced diabetes mellitus. Toxicol Appl Pharmacol (2004); 197: 67-83.
- Bhattacharyya MH. Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures. Toxicol Appl Pharmacol (2009); 238: 258-265.
- Shinkai Y, Kaji T. Cellular defense mechanisms against lead toxicity in the vascular system. Biol Pharm Bull (2012); 35: 1885-1891.
- Osman K, Akesson A, Berglund M, Bremme K, Schütz A, Ask K, Vahter M. Toxic and essential elements in placentas of Swedish women. Clin Biochem (2000); 33: 131-138.
- Mozaffarian D. Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions. Int J Environ Res Public Health (2009); 6: 1894-1916.
- Cohen JT, Bellinger DC, Shaywitz BA. A quantitative analysis of prenatal methyl mercury exposure and cognitive development. Am J Prev Med (2005); 29:353–365.
- Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health (2009); 24:15–45.
- Roosli M. Non-cancer effects of chemical agents on children’s health. Prog Biophys Mol Biol (2011); 107:315–322.
- Julvez J, Grandjean P. Neurodevelopmental toxicity risks due to occupational exposure to industrial chemicals during pregnancy. Ind Health (2009); 47:459–468.
- Pan J, Song H, Pan XC. Reproductive effects of occupational exposure to mercury on female workers in China: a meta-analysis. Zhonghua Liu Xing Bing Xue Za Zhi (2007); 28:1215–1218.
- Borja-Aburto VH, Hertz-Picciotto I, Rojas LM, Farias P, Rios C, Blanco J. Blood lead levels measured prospectively and risk of spontaneous abortion. Am J Epidemiol (1999); 150:590–597.
- Needleman HL, Rabinowitz M, Leviton A, Linn S, Schoenbaum S. The relationship between prenatal exposure to lead and congenital anomalies. JAMA (1984); 251:2956–2959.
- Bellinger DC. Teratogen update: lead and pregnancy. Birth Defects Res A Clin Mol Teratol (2005); 73:409–420.
- Hernandez-Avila M, Peterson KE, Gonzalez-Cossio T, Sanin LH, Aro A, Schnaas L, Hu H. Effect of maternal bone lead on length and head circumference of newborns and 1-month-old infants. Arch Environ Health (2002); 57:482–488.
- Kennedy DA, Woodland C, Koren G. Lead exposure, gestational hypertension and pre-eclampsia: a systematic review of cause and effect. J Obstet Gynaecol (2012); 32:512–517.
- Bellinger D, Leviton A, Needleman HL, Waternaux C, Rabinowitz M. Low-level lead exposure and infant development in the first year. Neurobehav Toxicol Teratol (1986); 8:151–161.
- Gundacker C, Hengstschläger M. The role of the placenta in fetal exposure to heavy metals. Wien Med Wochenschr (2012); 162: 201-206.
- Takiguchi M, Yoshihara S. New aspects of cadmiumas endocrinedisruptor. Environ Sci (2006); 13: 107-116.
- Stasenko S, Bradford EM, Piasek M, Henson MC,Varnai VM, Jurasovic J, Kusec V. Metals inhumanplacenta: focus onthe effects of cadmium on steroid hormones and leptin. J Appl Toxicol (2010); 30: 242-253.
- Kordas K, Lonnerdal B, and Stoltzfus R.Interactionsbetween Nutrition and Environmental Exposures: Effects on Health Outcomes in Women and Children. Journal of Nutrition(2007); 137, no. 12, pp. 2794–2797.
- Reddy Y, Aparna Y, Ramalaksmi B, and DineshKumar B,Lead and trace element levels in placenta, maternal and cordblood: A cross-sectional pilot study. Journal of Obstetrics and Gynaecology Research (2014)vol. 40, no. 12, pp. 2184–2190.
