The relationship of maternal age and some other associated factor to down syndrome

Abstract

: Down syndrome is the most common genetic disorder in the world caused by abnormalities in the chromosome. Genetic disorders can be caused by trisomy 21, translocation, and mosaic. Trisomy 21 is characterized by an excess number of the 21st chromosome due to the nondisjunction where 21st chromosome fails to separate from the homologous chromosome; the incidence reaches 95% of the total Down Syndrome incidences in the world. Down syndrome is a multifactorial disease, including maternal and paternal age, environment, radiations and chemicals. The most common factor that increases the risk of Down syndrome is the age of mother.

In this study is based on the causes behind the genetic disease Down syndrome, Cases were collected from a special center for the rehabilitation of children with special needs in the city of Tobruk wherears were found about 200 cases of Down syndrome of rehabilitation of children with special needs in the city of Tobruk. In general, it was grouped according to the child's sex, maternal age, consanguinity and Family hisory exposure to chemical substance during pregnant.

Although advanced maternal age is an established risk factor for DS, the present study showed that young mothers between 30 to 34 are also susceptible. Further studies are required to confirm these findings.