The effect of paracetamol on the kidney tissues of male albino rats and the protective effect of vitamin C
الكلمات المفتاحية:
الأنسجة المرضية ،، الباراسيتامول ،، فيتامين ج ،، الكلية ،، الجرذان.الملخص
: فيتامين ج هو أحد مضادات الأكسدة الطبيعية الموجودة في الحمضيات والفواكه اللينة والخضروات ذات الأوراق الخضراء وقد أظهر آثارًا وقائية ضد السمية الكلوية التي تسببها الأدوية المختلفة. تهدف الدراسة إلى معرفة التأثير الوقائي المحتمل لـفيتامين ج ضد التلف الكلوي الناجم عن الباراسيتامول في الجرذان. 40 من ذكور الجرذان تم تقسيمها إلى خمس مجموعات: المجموعة (1) كمجموعة ضابطة. تلقت الحيوانات الماء المقطر عن طريق الفم، المجموعة (2)؛ تلقت 500 مجم / كجم من فيتامين ج. المجموعة (3)؛ تلقت الجرذان 500 مجم / كجم من الباراسيتامول. المجموعة (4) (مجموعة الحماية)؛ تلقت فيتامين ج لمدة 7 أيام، ثم أعطيت الباراسيتامول لمدة 7 أيام أخرى، عوملت المجموعة (5) بمزيج من فيتامين ج والباراسيتامول لمدة 14 يومًا. أظهرت الأنسجة الكلوية للجرذان المعاملة بالباراسيتامول تنكسًا في الكريات الكلوية مع اتساع مساحة محفظة بومان، وتوسع الشعيرات الدموية حول الأنبوب، واحتقانها، وتقشر الظهارة الأنبوبية الكلوية مع تلف حدود الفرشاة للخلية ووجود حطام في التجويف الأنبوبي. واظهرت الجرذان في مجموعة الحماية البنية الكلوية الطبيعية تقريبًا لكل من القشرة والنخاع، بينما أظهرت الجرذان المعاملة بفيتامين ج مع الباراسيتامول بعض التغيرات في هيكل الكلية. في الختام، أظهر فيتامين ج كمضاد للأكسدة حماية للكلية من تلف الأنسجة الناجم عن الباراسيتامول.
المراجع
References:
Abdullah, B. A., Wadi, S. A. and Sarhat, E. R. Histological study effects of paracetamol on livers and kidneys of adult mice. Tikrit Journal for Agricultural Sciences. 2017. 17: 97-103.
Adeneye, A. A. and Olagunju, J. O. Protective effect of oral ascorbic acid (vitamin C) against acetaminophen-induced hepatic injury in rats. African Journal of Biomedical Research. 2008. 11: 183-190.
Adeneye, A. A. and Olagunju, J. Protective effect of oral ascorbic acid (vitamin C) on acetaminophen-induced renal injury in rats. African Journal of Biomedical Research. 2009. 12(1): 55-61.
Al-Asmari, A. K., Al-Said, M. S., Abbasmanthiri, R., Al-Buraidi, A., Ibrahim, K. E. and Rafatullah, S. Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol induced hepatorenal toxicity in rats. Clinical Phytoscience. 2020. 6(16): 2-12.
Al-Eryani, M. A. Y., Shediwah, F. M. H., Al-Awar, M. S. A., Salih, E. M. A. and AL- Shaibani, E. A. S. The ability of vitamin A, alone or in combination with vitamins C and E, in ameliorating the side effects of penicillin and streptomycin on hepatic damage in guinea pigs. Jordan Journal of Biological Sciences. 2014. 7(2): 127-132.
Asiley, S. B., Elliot, R. M., Archer, D. B. and Southon, S. Evidence that dietary supplementation with carotenoids-rich food modulates the DNA damage: Repair balance in human lymphocytes. British Journal of Nutrition. 2004. 91: 63-72.
Aydin, G., Gökçìmen, A., Meral Öncü, A. G., Çìçek, E., Karahan, N. and Gökalp, O. Histopathologic changes in liver and renal tissues induced by different doses of diclofenac sodium in rats. Turkish Journal of Veterinary and Animal Sciences. 2003. 27: 1131-1140.
Bashandy, S. A., Amin, M. M., Morsy, F. A. and El-Marasy, S. A. Amelioration of the nephrotoxic effect of potassium dichromate by whey protein and/or Nigella sativa oil in male albino rats. Journal of Applied Pharmaceutical Science. 2016. 6 (8): 44-50.
Boutis, K. and Shannon, M. Nephrotoxicity after acute severe acetaminophen poisoning in adolescents. Journal of Toxicology: Clinical Toxicology. 2001. 39(5):441-445.
Caskurlu, T., Kanter, M., Erboga, M., Erboga, Z. F., Ozgul, M. and Atis, G. Protective effect of Nigella sativa on renal reperfusion injury in rat. Iranian Journal of Kidney Diseases. 2016. 10 (3): 135-143.
Cherubini, A., Vigna,G. B., Zuliani, G., Ruggiero, C., Senin, U. and Fellin, R. Role of antioxidants an atherosclerosis: epidemiological and clinical update. Current Pharmaceutical Design. 2005. 11:2017-2032.
Dortaj, H., Anvari, M., Yadegari, M., Sharifabad, M. H. and Sarcheshmeh, A. A. Stereological Survey of the Effect of Vitamin C on neonatal rat kidney tissue treated with acrylamide. Modern medical laboratory journal. 2017. 1(2): 42-49.
Farooqui, Z., Afsara, M., Rizwana, S., Khanb, A. A. and Khana, F. Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver. Toxicology Reports. 2016. (3): 328-335.
Halliwell, B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Ageing. 2001. 18(9): 685-716.
Hasan, M. N., Khan, R. A. and Nasiruddin, M. Ameliorative effect of Nigella sativa oil against paracetamol induced hepatic and renal damages in rats. British Journal of Pharmaceutical Research1. 2016. 3(3): 1-10.
Hassan, D. H., Omar, A. Z., Gallaly, D. Q., Ahmad, S. R. and Maulood, I. M. Histological impacts of L-arginine, vitamin C and their combination on liver and kidney of paracetamol treated rats. Journal of Pure and Applied Sciences. 2020. 32(6): 40-45.
Johnson, M., Olufunmilayo, L. A., Anthony, D. O. and Olusoji, E. O. Hepatoprotective effect of ethanolic leaf extract of Vernonia amygdalina and Azadirachta indica against acetaminophen-induced hepatotoxicity in Sprague-Dawley male albino rats. American Journal of Pharmacological Sciences. 2015. 3(3): 79-86.
Kaniz, F. U., Mahboob, S., Hossain, K., Bhusal, B. and Hamid, K. Antioxidant activity and brine shrimp lethality bioassay of different parts of the plant Calotropis gigantea R. Journal of Pharmaceutical Sciences and Research. 2012. 4(12): 2004-2008.
Khalaf, G. and Mostafa, H. K. K. Histological and immunohistochemical study on the effect of passive smoking on the skin of adult male albino rats and the possible protective role of Nigella sativa oil. Egyptian Journal of Histology. 2012. 35:87-94.
Kumar, V., Abbas, A. K., Fauston, N. and Mithchell, R. N. Text book of Robbins basic pathology, 8th Ed. Published by Elsevier, a division of reed and Elsevier India private Ltd: 2012. 559-567.
Lillie, R. D. Histopathological technigues and practical histochemistry. Mc Graw-Hill. U.S.A. 1954.
Loh, C. S. and Ponampalam, R. Nephrotoxicity associated with acute paracetamol overdose: A case report and review of the literature. Hong Kong Journal of Emergency Medicine. 2006. 13(2): 105-110.
Lorz, C., Justo, P., Sanz, A., Subira, D., Egido, J. S. and Ortiz, A. Paracetamol-induced renal tubular injury: A role for ER stress. Journal of the American Society of Nephrology. 2004. 15: 380-389.
Majeed, S. K., Ramadhan, M. A. and Monther, W. Long-term toxicological effects of paracetamol in rats. Iraqi Journal of Veterinary Sciences. 2013. 27(1): 65-70.
Modo, E., Okwandu, N. and Dongo, B. Comparative effects of vitamin C and vitamin E pre-treatment in acute paracetamol induced toxicity on the liver of rats. World Journal of Pharmaceutical Sciences. 2015. 3(3): 407-412.
Moshaie-Nezhad, P., Bahari, Z., Jangravi, Z., Zarei, S. M. and Iman, M. J. The effect of Descurainia Sophia seed extract on nephrotoxicity markers induced by acetaminophen in mice. Journal of Advances in Medical and Biomedical Research. 2021. 29(134): 139-144.
Odigie, E. B., Peter U. and Achukwu, P. U. Histopathological effects of acetaminophen abuse in male Wistar rats, and prevalence in human subjects: An experimental and cross‑sectional study. Journal of Experimental and Clinical Anatomy. 2015. 14:81-87.
Prior, R. L. and Cao, G. Antioxidant phytochemicals in fruits and vegetables; diet and health implications. Horticultural Science. 2000. 35: 588-592.
Rekha, R. S., Raina, A. and Hamid, S. Histopathological effects of pesticide-cholopyrifos on kidney in albino rats. International Journal of Research in Medical Sciences. 2013. 1(4): 465-475.
Sabiu, S., O’Neill, F. H. and Ashafa, A. O. T. Membrane stabilization and detoxification of acetaminophen-mediated oxidative onslaughts in the kidneys of Wistar rats by standardized fraction of Zea mays L. (Poaceae), Stigma maydis. Evidence-Based Complementary and Alternative Medicine. 2016. 1-14.
Sheweita, S. A. Drug-metabolizing enzymes: Mechanisms and functions. Current Drug Metabolism. 2000. 1(2): 107-132.
Stangeland, T., Remberg, S. F. and Lye, K. A. Total antioxidant activity in 35 Ugandanfruits and vegetables. Food Chemistry. 2008. 113: 85-91.
Tittarelli, R., Pellegrini, M., Scarpellini, M. G., Marinelli, E., Bruti, V. Di luca, N. M., Busardò, F. P. and Zaami, S. Hepatotoxicity of paracetamol and related fatalities. European Review for Medical and Pharmacological Sciences. 2017. 21 (1): 95-101.
Tsvetkova, B., Pencheva, I., Zlatkov, A. and Peikov, P. Simultaneous high-performance liquid chromatography determination of paracetamol and ascorbic acid in tablet dosage forms. African Journal of Pharmacy and Pharmacology. 2012. 6(17):1332-1336.
Waheed, R. M., Bakery, H. H., El-Shawarby, R. M. and Abou Salem, M. E. Toxicity of lambda cyhalothrine on erythrogram, liver and kidney with molorated by vitamin C. Benha Veterinary Medical Journal. 2011. 22(2): 238-248.
Woollard, K. J., Loryman, C. J., Meredith, E., Bevan, R., Shaw, J. A., Lunec, J. and Griffith, H. R. Effects of oral vitamin C on monocyte: Endthelial cell adhension in healthy subjects. Biochemical and Biophysical Research Communications. 2002. 294: 1161-1168.
Xavier, S. M., Barbosa, C. O., Barros, D. O., Silva, R. F., Oliveria, A. A. and Freitas, R. M. Vitamin C antioxidant in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine. Neuroscienc
