Syntheses, Characterizations and Antimicrobial Activity of Three New Mixed Ligand Fe(III) Ce(IV) and Th(IV) Schiff Base Chelates

  • Bahya M. ALfakhry Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya
  • Miloud M. Miloud Department of Botany, Faculty of Science, Benghazi University-Al-abyar branch, Benghazi, Libya
  • Marei M. El-ajaily Department of Chemistry, Faculty of Science, Benghazi University, Benghazi, Libya
  • Najla M. Mohamed Department of Chemistry, Faculty of Science, Benghazi University-Tawkra branch, Benghazi, Liby
  • Asma ELramli Laboratory of Alakeed medical, Benghazi, Libya
  • Esraa ELwerfally Laboratory of Alakeed medical, Benghazi, Libya
الكلمات المفتاحية: Schiff base،, Ethylenediamine،, Mixed ligand chelates،, Antimicrobial activity،, MIC


In the present study, a Schiff base (HL1) derived from the condensation reaction      of L-alanine with o-hydroxyacetophenone  in 1:1 molar ratio was synthesized. The Schiff base and ethylenediamine compound were used to form three mixed ligand chelates with iron(III), cerium(IV) and thorium(IV) ions. The compounds were characterized using several analytical and spectroscopic tools [IR, electronic, NMR and mass]. The results showed the bonding behavior between the ligands and metal ions. The antimicrobial activities of the ligands and mixed ligand chelates were investigated against Staphylococcus aureus, Serratia marcescens, Acinetobacter baumannii and Candida albicans using the agar disk diffusion method. The results indicated that the antimicrobial activity of the tested compounds exhibited a fairly good inhibitory effect on the pathogenic microbe’s species. In contrast, the L-alanine showed no antimicrobial activity against A.baumannii. Schiff base, L-alanine, o-hydroxy acetophenone , [Fe(L1) (L3)(OH)] .H2O, [Ce(L1) (L3)(SO4)(H2O)].H2O and [Th(L1)(L3)(NO3)2]. 2H2O showed bacteriostatic activity against the highly susceptible species of pathogenic bacteria (S. aureus and S. marcescens) with MIC reached 50 mg/ml. while ethylenediamine suppressed bacterial growth of these species at a concentration of 25 mg/ml.


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