Risk Factors for Ciprofloxacin and Gentamycin Resistance among Gram Positive and Gram Negative Bacteria Isolated from Community-Acquired Urinary Tract Infections in Benghazi city

  • Abdlmanam Fakron Omar Al-Mukhtar University, Faculty of Science, Department of Microbiology, Box 919, Al-Bayda – Libya
  • Noor Alawkally Department of Medical laboratory, High Institute of Science and Technology, Suluq, Libya
  • Sara El- warred Department of Statistic, Faculty of Arts and Science, University of Benghazi, Libya.
  • Mareei Aldouakali Ali Department of Medical laboratory, High Institute of Science and Technology, Suluq, Libya.
  • Mailud El-amari Department of Health Education , Faculty of Public Health, University of Benghazi, Libya
  • Alreda Awkally Central of Pharmacy, Ministry of Health, Darna, Libya
  • Mohammed Soutiyah Department of Microbiology, Faculty of Science, University of Omar Al-mukhtar, Libya
  • Nessrine Suliman Department of Zoology- Faculty of Science- University of Benghazi, Libya
  • Hamza Ibrahim Hamza Khalifa Ibrahim4Department of Pharmacy, Higher Institute of Medical Technology, Bani Waleed, Libya
Keywords: Benghazi, Ciprofloxacin, Gentamycin, E. coli, Klebseilla pneumonia, Staph aureus, Urinary Tract Infection

Abstract

Urinary tract infections (UTIs) are a severe public health problem caused by a range of pathogens. The aims of the study were to investigate the prevalence of urinary tract infection and to see the pattern of Ciprofloxacin and Gentamycin susceptibility against uropathogens in Benghazi city. The study took place between 2021 April and October 2021. In-vitro antibacterial activity and resistance patterns of these two well-known antibiotics were studied and compared using the disk diffusion method. Laboratory reports and clinical data of patients with a positive urine culture (≥105 CFU/mL) were included in the study. Ciprofloxacin and gentamycin were tested against fourteen common bacterial pathogens, isolated from clinical samples of patients from Benghazi city Libya. A total of isolates were detected in 264 (75.4%) samples. Out of these, 75.4% were female and 24.6% were male. The majority of the study participants were in the age range of between 36-53 years (33.7%). The Increased bacterial resistance to ciprofloxacin has been shown. Most strains of E. coli and Staph aureus were resistant to ciprofloxacin and sensitive to gentamycin thereby showing that gentamycin is more effective than ciprofloxacin. This study showed that E. coli followed by staph aureus and K. pneumonia were the predominant uropathogen of UTIs in this geographical area. Most of the uropathogens were susceptible to Ciprofloxacin. The results showed that there is an alarming subject of resistance to Gentamicin against UTI patients in this area. Clinicians should be aware of the existing data and treat patients according to susceptibility patterns.

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Published
2022-04-17
How to Cite
[1]
Fakron, A., Alawkally, N., El- warred, S., Aldouakali Ali , M., El-amari , M., Awkally, A., Soutiyah, M., Suliman, N. and Ibrahim, H. 2022. Risk Factors for Ciprofloxacin and Gentamycin Resistance among Gram Positive and Gram Negative Bacteria Isolated from Community-Acquired Urinary Tract Infections in Benghazi city. Scientific Journal for the Faculty of Science-Sirte University. 2, 1 (Apr. 2022), 76-87. DOI:https://doi.org/10.37375/sjfssu.v2i1.204.
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